ABOUT 19 YEARS AGO, AT THE AGE OF 21, Mark Horowitz was very unhappy. He was studying to be a psychiatrist, but he felt his life was falling apart. Horowitz went to a family doctor and asked for a prescription for antidepressants. “She gave it to me in about 30 seconds,” he said. He cycled through a few different ones, each with its own side effects, before settling on escitalopram, known in the United States as Lexapro, a selective serotonin reuptake inhibitor, or SSRI.
In medical school in Sydney, Australia, Horowitz had heard the gospel about antidepressants and believed in the drugs. “I thought, ‘This is going to be the answer,’” he told me. “I read things on the Internet, in textbooks. I thought, ‘This is going to solve it…