IT’S HARD TO RECALL A TIME BEFORE BRCA. IN THE two decades since testing for the gene mutations—BRCA1 and BRCA2—linked to breast and ovarian cancers became available, tens of thousands of women whose results came back positive have elected to undergo prophylactic surgery, giving rise to the term previvors. After Angelina Jolie’s 2013 public revelation that she’d joined their ranks, a 64 percent increase in BRCA testing in the general population ensued, according to a 2016 Harvard Medical School study.
Meanwhile, BRCA’s quiet cousin, Lynch syndrome, with gene alterations also linked to ovarian cancer, remains little known. The syndrome puts people at higher risk for a variety of cancers—colon, uterine, ovarian, pancreatic, stomach, liver, bladder, upper urinary tract, skin, and, in rare cases, brain. This diffusion has made it harder…